Job Description Summary
The Langdon Laboratory in the Dr. Charles P. Darby, Jr. Department of Pediatrics, Hollings Cancer Center, and Darby Children’s Research Institute at the Medical University of South Carolina seeks a highly motivated Postdoctoral Scholar to further the Langdon Laboratory mission: to elucidate the mechanisms driving pediatric cancer signaling and tumorigenesis and to identify potentially targetable therapeutic vulnerabilities.Entity
Medical University of South Carolina (MUSC - Univ)Worker Type
EmployeeWorker Sub-Type?
RegularCost Center
CC001013 COM PEDS Children's Research Institute CCPay Rate Type
SalaryPay Grade
University-00
Pay Range
$0 - $0 - $0Scheduled Weekly Hours
40Work Shift
Job Description
The Langdon Laboratory in the Dr. Charles P. Darby, Jr. Department of Pediatrics, Hollings Cancer Center, and Darby Children’s Research Institute at the Medical University of South Carolina seeks a highly motivated Postdoctoral Scholar to further the Langdon Laboratory mission: to elucidate the mechanisms driving pediatric cancer signaling and tumorigenesis and to identify potentially targetable therapeutic vulnerabilities. The successful Scholar candidate should have a PhD or equivalent degree, be eligible to work in the United States, and have extensive training in molecular biology techniques, cell-based functional assays, mammalian tissue culture, and murine husbandry, with a preference for scientists with a cancer biology training background. The Langdon Laboratory uses a combination of pharmacological and genetic perturbations in human cancer cell lines and patient-derived xenograft model systems to achieve our laboratory’s experimental goals. The successful candidate will develop an independent research project thematically related to the overarching goals of the Laboratory. The successful candidate will also be expected to support and supervise graduate and undergraduate trainees with specific tasks, experimental procedures, and laboratory maintenance. The candidate will report to and be directly supervised by the laboratory’s Principal Investigator, Dr. Casey Langdon, PhD. The Langdon Laboratory is committed to fostering a welcoming, diverse, and inclusive laboratory culture, as well as to enthusiastically support all trainees in the laboratory.
Minimum requirements: Doctoral degree and experience working with Pediatric Cancer.
35% effort:
Develops an independent research project (in collaboration with Dr. Langdon) using available model systems in the laboratory including sarcoma cell lines, patient derived xenografts, pharmacological agents, and genetic perturbations. This includes performing in vitro mammalian tissue culture-based experiments (such as immunoblotting, qRT-PCR, cell viability or toxicity assays, etc.) and in vivo immunocompromised mouse-based experiments (such as injecting shRNA-transduced cell lines or treating xenografted mice with pharmacological agents). The candidate will be expected to design, execute, troubleshoot, analyze, and interpret research findings to Dr. Langdon and the Laboratory group. Organized, accurate, and precise record keeping is essential for the successful candidate.
35% effort:
Collaborates with other members of the laboratory to assist their projects with the candidate’s expertise, preparing experiments, and mentoring junior members of the laboratory. This also includes attending weekly one-on-one meetings with Dr. Langdon, group lab meetings, plus departmental and Cancer Center seminars and retreats.
20% effort:
In cooperation with Dr. Langdon, prepares manuscripts (including writing, Figure generation, data analysis and interpretation, etc.), meeting abstracts and presentations for conferences, and assisting with grant writing for both Dr. Langdon and the candidate’s own fellowship applications.
10% effort:
Helps with laboratory maintenance, space clean-up, and regulatory compliance, including Responsible Conduct of Research training.
Additional Job Description
Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 15 lbs., unassisted. (Frequent) Ability to lift objects, up to 15 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 15 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 15 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 15 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent) Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required.If you like working with energetic enthusiastic individuals, you will enjoy your career with us!
The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.
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