Job Description Summary
The Department of Biochemistry & Molecular Biology at the Medical University of South Carolina (MUSC) has an opening for a motivated and collegial Postdoctoral fellow in cancer immunology to join the laboratory of Dr. Tim Barnoud. The Barnoud lab focuses on the p53 tumor suppressor, the most frequently mutated gene in human cancer. Specifically, the lab is seeking to understand the impact of genetic variants of p53 on the tumor microenvironment and response to cancer immunotherapy. A second goal of the Barnoud lab is to identify novel therapeutic strategies in gastrointestinal (GI) cancers, including the role of heat shock proteins in pancreatic and liver cancer. The candidate should be highly motivated with a recent Ph.D. degree, or a Graduate Student about to receive a Ph.D. degree, with a solid background in cancer biology and/or immunology. Experience with flow cytometry and genetically engineered mouse models (GEMMs) is highly desirable.Entity
Medical University of South Carolina (MUSC - Univ)Worker Type
EmployeeWorker Sub-Type?
RegularCost Center
CC000954 COM BIOCHEM Operations CCPay Rate Type
SalaryPay Grade
University-00
Pay Range
$0 - $0 - $0Scheduled Weekly Hours
40Work Shift
Job Description
Job Description:
The Department of Biochemistry & Molecular Biology at the Medical University of South Carolina (MUSC) has an opening for a motivated and collegial Postdoctoral fellow in cancer immunology to join the laboratory of Dr. Tim Barnoud. The Barnoud lab focuses on the p53 tumor suppressor, the most frequently mutated gene in human cancer. Specifically, the lab is seeking to understand the impact of genetic variants of p53 on the tumor microenvironment and response to cancer immunotherapy. A second goal of the Barnoud lab is to identify novel therapeutic strategies in gastrointestinal (GI) cancers, including the role of heat shock proteins in pancreatic and liver cancer. The candidate should be highly motivated with a recent Ph.D. degree, or a Graduate Student about to receive a Ph.D. degree, with a solid background in cancer biology and/or immunology. Experience with flow cytometry and genetically engineered mouse models (GEMMs) is highly desirable.
Minimum Requirements:
PhD or Equivalent
Job Duties:
25%- Collaborates with the PI and other lab members involved to design and execute experiments using state-of-the-art genetically engineered mouse models, and cells prepared form these models, to study the role of p53 variants in cancer risk, with a focus on gastrointestinal (GI) cancers. These duties include genotyping of genetically engineered mice and animal husbandry, in vivo experiments, including treatment studies, monitoring for development of disease, necropsies of experimental mice and in vitro studies, including preparing cells from the models, cell culture, flow cytometry, molecular and functional genomic evaluation of gene expression and transcription factor binding to target genes, including, RNA-Seq, ChIP-Seq, and proteomics.
25%- Collaborates in the generation of novel HSP70 inhibitors and their impact on the initiation, progression, and metastasis of GI and other solid tumors. Performs in vitro and in vivo experiments to determine efficacy and safety of inhibitors, either alone or in combination with other therapeutic agents. Performs multi-omic analysis of genetic and/or pharmaceutical ablation of heat shock proteins and its impact on cell biology.
20%- Collaborates in collecting and analyzing data generated from the experiments. Duties include keeping accurate records on a daily basis, using appropriate software for analysis of data, and collaborating with Biostatistics and Bioinformatics Research Shared Resources to ensure quality of the results, interpreting results, and planning new experiments.
20%- Collaborates in preparing manuscripts and grants based on the experimental data generated. Duties include keeping current with the literature, preparing figures based on data collected, writing manuscripts and sections of grants with the PI and senior team members, presenting current work in research in progress seminars, attending departmental seminars and participating in journal clubs.
10%- Helps with laboratory maintenance and regulatory compliance, i.e., ordering, cleanup of lab areas, maintenance of equipment, helping to prepare IACUC protocols and amendments when appropriate.
Additional Job Description
Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 15 lbs., unassisted. (Frequent) Ability to lift objects, up to 15 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 15 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 15 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 15 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent) Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required.If you like working with energetic enthusiastic individuals, you will enjoy your career with us!
The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.
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