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Job Description: Fully funded postdoctoral positions are immediately available in the Department of Neurosurgery at the Duke University School of Medicine. We are seeking candidates interested in leading projects based on advancing the development and application of focused ultrasound for non-invasive neuromodulation, ablation, and brain drug/gene delivery. The successful candidate will be an integral part of the research team, conducting independent experiments investigating focused ultrasound based neuromodulation, presenting at weekly lab meetings and research conferences, and working with collaborators at Duke and beyond.
Requirements: The applicant should have a Ph.D., M.D., or equivalent title in biomedical science or a related field. A highly motivated, independent candidate with a passion for translational neuroscience is preferred. Expertise in neurobiology, electrophysiology, mechanotransduction, ultrasound, or in vivo mouse work is highly desirable but not required.
Lab Background: We are a high-energy, highly passionate translational neuroscience lab focused on understanding the role of synaptic plasticity in neurologic disease and how this can be directly modulated for disease modification (Harward et al., Nature 2016; Hedrick et al., Nature 2016; Krishnamurthy et al., Ann Neurol 2019). We are particularly interested in developing focused ultrasound as a new method for non-invasively modulating brain activity. Briefly, Focused Ultrasound has recently emerged as a ground-breaking new non-invasive, image-guided therapy to treat Essential Tremor (ET) and Parkinson’s Disease (PD). While it is used clinically to make small lesions in the brain circuitry responsible for both ET and PD, additional work has shown that when applied at lower intensity and frequency, it can be used to transiently and focally (with sub-millimeter precision) to open the blood brain barrier, induce local immune responses, and even activate excitatory neurons, inhibitory interneurons, astrocytes, and even microglia. Building on this work, we seek to harness the power of this new tool to optimize its therapeutic use for a wide variety of conditions including epilepsy, neuropsychiatric disease, movement disorders, chronic pain, and brain tumors. To accomplish these goals, we employ a wide range of experimental approaches including viral infections, mouse genetics, in vitro and in vivo preparations, electrophysiology, calcium imaging, optogenetics, and focused ultrasound.
How to apply: If interested, please submit a cover letter describing your prior research experience and interests, your future research and career goals, and an expected starting date. Additionally, please submit a current CV and that name of three references.
See job description for education requirements.
See job description for requirements.
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