Job Description Summary
The department of Biochemistry & Molecular Biology at MUSC has an opening for a motivated and collegial Postdoctoral Fellow in the laboratory of Dr. Judit Jimenez Sainz, who will join MUSC on August 1st. The Jimenez Sainz lab focuses on the Breast Cancer Susceptible Gene 1/2 (BRCA1/2) and the Partner and localizer of BRCA2 (PALB2), caretakers of genome integrity which mutated lead to high risk of breast, ovarian, prostate, pancreatic and melanoma cancers. BRCA1/2and PALB2 are fundamental players in the repair of double strand breaks through its role in homologous recombination and replication to preserve DNA stability. Specifically, the lab is seeking to understand the impact of genetic variants in BRCA1/2 and PALB2 localization and functions to define cancer risk and response to therapy. A second goal of the Jimenez Sainz lab is to identify novel therapeutic strategies to sensitize tumor cells based on cellular mislocalization of BRCA1/2 andRAD51 (BRCA2 partner in homologous recombination). The third goal of the Jimenez-Sainz lab is to define the factors involved in the crosstalk between homologous recombination and replication machineries upon platinum drugs and PARP inhibitors.Entity
Medical University of South Carolina (MUSC - Univ)Worker Type
EmployeeWorker Sub-Type?
Research GrantCost Center
CC000952 COM BIOCHEM Administration CCPay Rate Type
HourlyPay Grade
University-05
Pay Range
$37,860 - $53,957 - $70,054Scheduled Weekly Hours
40Work Shift
Job Description
Job Duties -
· Performs mammalian tissue culture (25%)
- Grows, maintains, expands, and treats mammalian cell lines
- Develops, evaluates and implements new or modified culture procedures
- Improves laboratory methods of primary tissue culture
· Performs bacterial culture and cloning (20%)
- Grows bacteria and extracts DNA for molecular use.
- Clones the genetic variants into the phCMV1 backbone
· Performs DNA/RNA/Protein analysis (15%)
- Extracts DNA/RNA/Protein from mammalian cells.
- Analyzes DNA/RNA/Protein by PCR, Northern Blot, and Western Blot
· Prepares laboratory records (15%).
- Prepares daily records of experimental procedures and results
· Prepares laboratory buffers and solutions (10%).
- Prepares daily buffers, reagents, and solutions for the experimental procedures.
· Maintain laboratory supplies (10%).
- Orders and places laboratory supplies
· Upon request, performs other tasks requested by faculty to maintain a smooth operation of laboratory (5%).
- Performs collaborations with inside and outside colleagues
- Handling of unsealed radioactive materials and/or use of radiation producing equipment.
MUSC Minimum Training and Experience Requirements:
A bachelor's degree in chemistry, biology, or other natural, life or health care science and one year work experience directly related to the assigned research area.
MUSC Physical Requirements:
(Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift)
Ability to perform job functions in an upright position. (Frequent)
Ability to perform job functions in a seated position. (Continuous)
Ability to perform job functions while walking/mobile. (Frequent)
Ability to climb, using step stool. (Infrequent)
Ability to work in temperature extremes (32° F to 100° F) when required due to assignments in cold rooms and/or foreign countries. (Infrequent)
Ability to work in confined/cramped spaces. (Continuous)
Ability to bend at the waist. (Frequent)
Ability to twist at the waist. (Frequent)
Ability to fully use both hands/arms. (Continuous)
Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Frequent)
Ability to fully use both legs. (Frequent)
Ability to reach in all directions, stretch, bend, while moving items/materials from both sitting and standing positions. (Frequent)
Ability to maintain good olfactory sensory function/distinction. (Continuous)
Ability to lift materials up to 20 lbs., unassisted. (Infrequent)
Ability to lift and carry 4 liter waste material bottles a distance of 30 feet, unassisted. (Frequent)
Ability to lift and carry 25-30 lbs. jugs of liquid a distance of 100 feet, unassisted. (Infrequent)
Ability to lift file boxes, from floor level to counter tops, unassisted. (Frequent) Ability to push/
Ability to lift 40 lbs. centrifuge rotors from floor level to height of 40 inches, then down 20 inches into centrifuge drum, unassisted. (Infrequent)
Ability to lift 25 lbs. boxes, from floor level to maximum height of 72 inches, unassisted. (Infrequent)
Ability to push/pull file boxes from one location to another at floor level. (Frequent)
Ability to maneuver heavy equipment on bench tops, 50 lbs. or greater, unassisted. (Frequent)
Ability to perform gross motor functions with frequent fine motor movements. (Continuous)
Ability to maintain 20/40 vision, corrected, in one eye or with both eyes. (Continuous)
Ability to match or discriminate between colors, normally. (Continuous)
Ability to hear and recognize various alarms emitting from work area systems. (Continuous)
Ability to hear and/or understand conversations. (Continuous)
Ability to work in a darkroom for processing film, etc. (Continuous)
Ability to be qualified physically for respirator use, initially and annually. (Continuous)
Additional New Requirements:
Ability to work rotating shifts as required.
Ability to work overtime as required.
Ability to learn and use new processes, tools and equipment as required.
Additional Job Description
Minimum Requirements: A bachelor's degree in chemistry, biology, or other natural, life or health care science and one year work experience directly related to the assigned research area. Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Frequent) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb, using step stool. (Infrequent) Ability to work in temperature extremes (32° F to 100° F) when required due to assignments in cold rooms and/or foreign countries. (Infrequent) Ability to work in confined/cramped spaces. (Continuous) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Frequent) Ability to fully use both legs. (Frequent) Ability to reach in all directions, stretch, bend, while moving items/materials from both sitting and standing positions. (Frequent) Ability to maintain good olfactory sensory function/distinction. (Continuous) Ability to lift materials up to 20 lbs., unassisted. (Infrequent) Ability to lift and carry 4 liter waste material bottles a distance of 30 feet, unassisted. (Frequent) Ability to lift and carry 25-30 lbs. jugs of liquid a distance of 100 feet, unassisted. (Infrequent) Ability to lift file boxes, from floor level to counter tops, unassisted. (Frequent) Ability to push/ Ability to lift 40 lbs. centrifuge rotors from floor level to height of 40 inches, then down 20 inches into centrifuge drum, unassisted. (Infrequent) Ability to lift 25 lbs. boxes, from floor level to maximum height of 72 inches, unassisted. (Infrequent) Ability to push/pull file boxes from one location to another at floor level. (Frequent) Ability to maneuver heavy equipment on bench tops, 50 lbs. or greater, unassisted. (Frequent) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to maintain 20/40 vision, corrected, in one eye or with both eyes. (Continuous) Ability to match or discriminate between colors, normally. (Continuous) Ability to hear and recognize various alarms emitting from work area systems. (Continuous) Ability to hear and/or understand conversations. (Continuous) Ability to work in a darkroom for processing film, etc. (Continuous) Ability to be qualified physically for respirator use, initially and annually. (Continuous) Additional New Requirements: Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required.If you like working with energetic enthusiastic individuals, you will enjoy your career with us!
The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.
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